| Abstract: | An alcoholic extract obtained from rat skin contains epidermal g1- and g2-chalones, and when added to a suspension of cells of a transplantable squamous-cell keratinizing carcinoma of the mouse cervix uteri it inhibits its growth by 72.6% when injected into recipient mice. The extract had no inhibitory action on transplantable mouse tumors of other histogenesis (hepatoma 22a, leukemia L-1210, and sarcoma 180). Epidermal chalones had only weak action (inhibiting growth by 39.2%; P>0.05) on an anaplastic transplantable mouse skin carcinoma, which had lost its primary squamous-cell structure in the course of prolonged passage (more than 10 years).Laboratory of Experimental Tumors and Laboratory of Endocrinology, N. N. Petrov Research Institute of Oncology, Minsitry of Health of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR A. I. Serebrov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 10, pp. 466–468, October, 1977. |
