The pancreas and inflammatory bowel diseases |
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Authors: | Klaus R. Herrlinger and Eduard F. Stange |
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Affiliation: | (1) Division of Gastroenterology, Department of Internal Medicine I, Medical University of Luebeck, Ratzeburger Alee 160, 23538 Luebeck, Germany |
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Abstract: | Summary This article reviews the literature and gives an overview on prevalence and possible explanations for pancreatic involvement in inflammatory bowel diseases (IBD). IBD patients have a markedly elevated risk for developing acute pancreatitis as well as pancreatic insuffiency. Multiple potential causes for pancreatitis in IBD patients exist. In the majority of cases acute pancreatitis appears to be related to drug side effects or local structural complications rather than a true extraintestinal manifestation of IBD. Nevertheless, some cases of acute pancreatitis remain unexplained. Prevalence of chronic pancreatitis in IBD patients also seems to be relatively high. However, etiology of pancreatic duct changes and/or the occurrence of exocrine insufficiency remain unclear. In most cases chronic pancreatitis is clinically unapparent, although in some patients it may be accompanied by clinically relevant exocrine insufficiency. |
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Keywords: | Pancreas Crohn’ s disease ulcerative colitis side effects extraintestinal manifestation pancreatitis |
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