锌、硒、铬对糖尿病大鼠糖、脂代谢调节作用

目的 研究锌、硒、铬对糖尿病大鼠糖、脂代谢紊乱的影响并探讨其相关生化机制。方法 雄性Wistar大鼠52只，随机留取12只为正常对照组，其余大鼠以四氧嘧啶诱导成糖尿病模型，随机分为糖尿病对照组和3个实验组(糖尿病补锌组、糖尿病补硒组、糖尿病补铬组)。每日灌胃补充一定剂量的锌、硒、铬，实验期为60d。分别进行实验前后生化指标的检测，胰岛细胞的形态学观察。结果 锌、硒、铬对糖尿病大鼠的糖、脂代谢紊乱起到了一定的改善作用，补锌、补硒的效果优于补铬；锌、硒可提高糖尿病大鼠的抗氧化能力，减轻胰岛的病理损伤，而铬无明显作用。结论 锌、硒、铬通过不同的途径，对糖尿病大鼠糖、脂代谢的紊乱起到了不同程度的改善作用。

Regulation of zinc,selenium,chromium on disorders of blood glucose and lipid metabolism in diabetic rats

Objective To study the effects of zinc,selenium,chromium on glucose and lipid metabolism in diabetic rats,and its related biochemical mechanism.Methods 12 rats were randomly selected from 52 male Wistar rats as normal control group (NC group).The rest induced by alloxan into diabetic model were randomly divided into diabetic control group (DM group) treated with water and three other experimental groups (DM Zn group,DM Se group,DM Cr group) supplemented with zinc,selenium,chromium respectively by gavage daily for 60 days.At the end of the treatment,the blood biochemical analysis,pancreatic islets morphological observation were performed.Results Zinc,selenium,chromium could partially improve the disorders of glucose and lipid metabolism of diabetic rats.The effects of zinc and selenium supplement were much better than those of chromium supplement.Zinc,selenium could increase the antioxidant activity and alleviate pathological damage of pancreatic islets in diabetic rats,there was no change in DM Cr group.Conclusion Zinc,selenium,chromium could improve the disorders of glucose and lipid metabolism in varying degrees by different ways.