The nitric oxide-endothelin-1 connection |
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| Authors: | Alonso David Radomski Marek W |
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| Affiliation: | (1) Department of Integrative Biology and Pharmacology, University of Texas-Houston, USA |
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| Abstract: | Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors. |
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| Keywords: | nitric oxide endothelin vascular tone cardiovascular system receptor antagonist heart failure |
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