医院感染葡萄球菌临床分布特征及药敏试验分析

目的了解葡萄球菌医院感染的分布及耐药性，为临床合理使用抗生素、降低院内感染率提供参考依据。方法用VITEK-32型全自动微生物分析仪对临床分离的298株葡萄球菌进行鉴定和药敏试验。结果在298株葡萄球菌中分离出金黄色葡萄球菌159株（53．4％）、凝固酶阴性葡萄球菌（CNS）139株（46．6％）；CNS以表皮葡萄球菌、溶血葡萄球菌为主；金黄色葡萄球菌科室分布以外科病区为主；葡萄球菌耐药率达80．0％以上的抗菌素有：阿莫西林／棒酸、克林霉素、红霉素、头孢唑林、苯唑西林、青霉素；万古霉素敏感率为100．0％。结论葡萄球菌耐药率高，耐药谱广，应对其进行严密监测，合理用药，积极预防医院感染的发生。

Characteristics of distribution of hospital infected Staphylococcus and the sensitivity of drugs

Objective To analysis the distribution and resistance of staphylococcus from nosocomial infection tor the clinical rational use of antibiotic. Methods 298 strains of Staphylococcus isolated from Clinical samples were identified with VITEK-32 automated microbial evaluation instrument and performed drug susceptibility test, respectively. Results Of the 298 strains of Staphylococcus, 159 strains （53.4%）were Staphylococcus aureus and 139 strains （46. 6%） were coagulase negative Staphylococcus （CNS）. Most CNS were Staphylococcus epidermidis and Staphylococcus hemolyticus. Surgery was the most common infectious department. The resistant rate of Staphylococcus to amoxicillin/clavulanate, clindamycin, erythromycin, cefazolin, oxacillin, and penicillin were higher than 80. 0%. The susceptible rate to vancomycin was 100. 0%. Conclusion Most of staphylococcus in nosocomial infection resists most drugs, but it is sensitive to vancomycin.