膝骨关节炎滑液中可溶性晚期糖基化终末产物受体水平与其病变程度的相关性

背景:研究表明骨关节炎患者关节滑液内可溶性晚期糖基化终末产物受体水平可能与关节炎病变的严重程度存在负相关,但在中国报道较少。目的:观察膝关节骨关节炎患者关节滑液内可溶性晚期糖基化终末产物受体水平与其病变严重程度的关系。方法:共纳入46名膝关节骨关节炎患者及14名健康对照者,纳入的骨关节炎患者符合美国风湿病学会骨关节炎的临床诊断标准。采用Kellgren-Lawrence的标准对膝关节骨关节炎病变严重程度进行分级,使用人可溶性晚期糖基化终末产物受体水平酶联免疫吸附试剂盒在酶标仪下检测测关节滑液的可溶性晚期糖基化终末产物受体水平。结果与结论:膝关节骨关节炎患者关节滑液可溶性晚期糖基化终末产物受体水平较健康对照组显著降低(P<0.01),且与膝关节骨关节炎病变严重程度呈显著独立负相关(r=-0.587,P<0.01)。结果表明关节滑液可溶性晚期糖基化终末产物受体水平可能与膝关节骨关节炎病变的严重性和进展程度相关。

Correlation between soluble receptor for advanced glycation end products levels in synovial fluid and disease severity of knee osteoarthritis

BACKGROUND:Studies have demonstrated that soluble receptor for advanced glycation end products(sRAGE) levels in synovial fluid might be negatively associated with disease severity of knee osteoarthritis(OA).OBJECTIVE:To determine the correlation between sRAGE levels in synovial fluid of OApatients and disease severity.METHODS:A total of 46 OA patients and 14 healthy controls were enrolled.The OA was defined using the revised criteria of American Rheumatism Association for the classification of rheumatoid arthritis.The disease severity of OA was graded by Kellgren-Lawrence classification.sRAGE levels in synovial fluid were determined by enzyme-linked immunosorbent assay(ELISA).RESULTS AND CONCLUSION:sRAGE levels in synovial fluid were significantly lower in OA patients than in healthy controls(P < 0.01).sRAGE levels in synovial fluid were negatively associated with disease severity of OA(r= 0.587,P < 0.01).These results demonstrated that sRAGE levels might be associated with the severity and progression of knee OA.