骨填充材料修复骨肿瘤术后的骨缺损

背景:骨填充材料具有良好的生物活性、生物相容性、生物安全性和机械性能,可通过骨的传导及诱发新骨形成等作用实现骨的自身修复,是一种高效、安全、性价比较高的骨移植替代材料,可作为修复囊性破坏的良性骨肿瘤和瘤样病变术后缺损的修复材料进行更深入地研究及开发利用。目的:总结近年有关骨填充材料修复骨肿瘤术后骨缺损的研究进展。方法:由作者应用计算机检索维普数据库中与骨填充材料修复骨肿瘤术后骨缺损有关的文献,检索时限为1998-01/2009-10。检索关键词:骨填充材料,骨肿瘤,骨缺损。最终纳入22篇文献进入结果分析。结果与结论:应用同种异体骨、自体骨复合物修复骨肿瘤瘤段切除后骨缺损是一种具有较高临床应用价值的有效方法。同种异体骨作为可被宿主生物学吸收重建的永久性植入材料,其相对于其他材料有很大优势。对于四肢良性肿瘤切除后骨缺损的修复,尤其是较大的骨缺损是一种具有较高临床应用价值的植入材料。

Bone filling materials for bone defects after bone tumor resection

BACKGROUND: Bone filling materials have good bioactivity, biocompatibility, biological safety and mechanical properties, and can induce formation of new bones to realize a self-repair of bones. This kind of material is an efficient, safe, cost-effective bone substitute, and can be used as repair materials for bone defects following repair of benign cystic lesions and tumor-like lesions. OBJECTIVE: To summarize the progress in bone filling materials for bone defects following bone tumor resection. METHODS: A computer-based search of VIP databases from January 1998 to October 2009 was performed using "bone filling materials, bone tumor, bone defect" as keyWords to retrieve relevant articles about bone filling materials for bone defects after bone tumor resection. There were 22 articles involved in result analysis. RESULTS AND CONCLUSION: Allogeneic bone and autologous bone compound is a high-effective methods for bone defects after bone tumor segment resection in clinic. Allogeneic bone as a permanent implant material for bone reconstruction can be completely absorbed by the host, and has great advantages relevant to other materials. It is a implant material with high clinical value for bone defects due to benign tumor resection of the extremities, especially for large bone defects.