四种药物治疗骨质疏松模型大鼠股骨扭转力学特性对比

背景:骨质疏松的预防、诊断和治疗都需要了解药物治疗的效果。扭转力学性能指标是对药物治疗后骨质疏松质量评价的一种可靠方法。目的:观察不同药物治疗动物骨质疏松的疗效。方法:四五月龄雌性Wistar大鼠建立骨质疏松模型,以复方中药、阿仑膦酸钠、维生素K、钙剂进行治疗,饲养15周后处死大鼠,取大鼠股骨在扭转试验机上以1(°)/s进行扭转实验,实验结束后通过试验机测量变盘读取转矩和扭转角数据,试样破坏后观察试样的断口形貌。结果与结论:骨质疏松大鼠最大转矩、扭转角、切应力均低于正常大鼠(P<0.05),而经过复方中药或阿仑膦酸钠治疗后,最大转矩、扭转角、切应力得到恢复,但维生素K及钙剂治疗效果不明显。说明中药、西药、维生素K治疗动物骨质疏松模型大鼠均有一定疗效,钙剂效果不明显,中药的效果最好。

Comparison of reverses mechanical characteristics of the femur in osteoporosis rats treated with four kinds of medicines

BACKGROUND:The prevention,diagnosis and treatment for osteoporosis need to understand the effect of medicine treatment.The reverses mechanical characteristics index is a reliable method for evaluating quality of osteoporosis after drug treatment.OBJECTIVE:To observe the therapeutic effect of several drugs on the treatment of osteoporosis.METHODS:Female Wistar rats,with 4-5 months old,were established osteoporosis models and treated by traditional Chinese medicinal compound preparations(TCMCPs),alendronate,vitamin K and calcium.All rats were sacrificed at 15 weeks after medication.The femur of rats were tested by a torsion test machine at speed of 1(°)/s.The torque and torsion angle were read,and the fracture surface was observed after sample failure.RESULTS AND CONCLUSION:The maximum torque,the biggest angle of torsion,and the biggest shear stress of the osteoporosis rats were smaller than those of the normal rats(P < 0.05).After TCMCPs or alendronate treatment,the maximum torque,the biggest angle of torsion,and the biggest shear stress revived to normal levels,but vitamin K and calcium had no obviously effect on reverses mechanical characteristics.The anti-torsional section coefficient was not affected by model preparation or medication.The findings demonstrated that TCMCPs,alendronate,and vitamin K have certain curative effect on treating osteoporosis,the calcium effect is not obvious,and the TCMCPs is best.