The 223A>G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease |
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Authors: | Yan-Ming Sun Lan-Feng Wang Jia Li Zhu-Qin Li Wei Pan |
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Affiliation: | (1) Department of Cardiac Care Unit, First Clinical Hospital of Harbin Medical University, 23 Post Rd., Nangang Region, Harbin, 150001, China |
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Abstract: | Objective To investigate whether leptin receptor (LEPR) 223A>G polymorphism influences serum lipid levels and whether this polymorphism affects the effectiveness of simvastatin in Chinese patients with coronary heart disease (CHD). Methods A total of 312 patients with CHD were treated with simvastatin 20 mg/day. Fasting serum lipids were determined before and after 12 weeks of treatment. Results Patients with AA genotype had significantly higher total cholesterol (TC) levels and lower high-density lipoprotein cholesterol (HDL-C) levels than those with GG genotype (P < 0.05) before simvastatin treatment. In addition, the ability of simvastatin to increase HDL-C levels was significantly lower in patients with AA genotype than those with GG genotype (P < 0.05). Conclusions The 223A>G polymorphism of LEPR significantly modulates the HDL-C response to simvastatin in Chinese patients with CHD. Yan-Ming Sun and Jia Li contributed equally to this study. |
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Keywords: | HMG-CoA reductase inhibitor Genetic polymorphism Leptin receptor Coronary heart disease |
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