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| 北方汉族泛发型白癜风与HLAⅠ、Ⅱ类等位基因相关性研究 | |
| 引用本文： | 王珺,赵玉铭,王岩,肖毅,王雅坤,陈洪铎.北方汉族泛发型白癜风与HLAⅠ、Ⅱ类等位基因相关性研究[J].中华医学遗传学杂志,2007,24(2):221-223. |
| 作者姓名： | 王珺 赵玉铭 王岩 肖毅 王雅坤 陈洪铎 |
| 作者单位： | 1. 110003,沈阳市第七人民医院皮肤科 2. 110001,沈阳,中国医科大学附属第一医院皮肤科 3. 中国医科大学盛京医院皮肤科 |
| 摘 要： | 目的探讨北方汉族泛发型白癜风与HLAⅠ、Ⅱ类等位基因的相关性。方法采用聚合酶链反应-序列特异引物技术检测34例北方汉族泛发型白癜风患者及102名健康人的HLA-A、B、Cw、DRB1和DQB1等位基因。结果与正常对照比较，泛发型白癜风患者HLA-A＊30、Cw＊06、DRB1＊07、DQBC＊0201基因频率显著增高，其中家族史阴性患者HLA-A＊30、Cw＊06、DRB1＊07、DQBC＊0201基因频率显著增高，但家族史阳性患者的等位基因频率差异无统计学意义。结论HLA—A＊30、Cw＊06、DRB1＊07、DQB1＊0201等位基因与北方汉族泛发型白癜风相关，可能是其易感基因或与泛发型白癜风的易感基因相连锁。 |
| 关 键 词： | 泛发型白癜风 人类白细胞抗原 等位基因 聚合酶链反应-序列特异引物 |
| 修稿时间： | 2006-07-04 |
Association of HLA class Ⅰ and Ⅱ alleles with generalized vitiligo in Chinese Hans in north China |
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| WANG Jun,ZHAO Yu-ming,WANG Yan,XIAO Yi,WANG Ya-kun,CHEN Hong-duo.Association of HLA class Ⅰ and Ⅱ alleles with generalized vitiligo in Chinese Hans in north China[J].Chinese Journal of Medical Genetics,2007,24(2):221-223. | |
| Authors: | WANG Jun ZHAO Yu-ming WANG Yan XIAO Yi WANG Ya-kun CHEN Hong-duo |
| Institution: | 1.Department of Dermatology, No.1 Hospital of China Medical University , Shenyang , Liaoning , 110001 P. R. China; 2. Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110001 P. R. China |
| Abstract: | OBJECTIVE: To investigate the association of HLA class I and II alleles with generalized vitiligo in ethnic Han Chinese in north China. METHODS: By employing polymerase chain reaction sequence-specific primer (PCR-SSP) procedure 34 generalized vitiligo patients in north China were studied for HLA I and II alleles and were compared with 102 healthy controls. RESULTS: The allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls. CONCLUSION: These alleles positively associated with generalized vitiligo in Chinese Han patients in north China, might provide clues to reveal the susceptibility gene(s) of vitiligo in Chinese and as well as the immunnogenetic mechanisms of disease. |
| Keywords: | generalized vitiligo human leucocyte antigen allele PCR-sequence specific primer |
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