| 双磷酸盐对接受去势治疗的激素敏感型前列腺癌患者防治骨质丢失的研究进展 |
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| 引用本文： | 赵欣,马建辉. 双磷酸盐对接受去势治疗的激素敏感型前列腺癌患者防治骨质丢失的研究进展[J]. 癌症进展, 2008, 6(6): 619-624 |
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| 作者姓名： | 赵欣 马建辉 |
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| 作者单位： | 中国医学科学院,北京协和医学院,肿瘤医院泌尿外科,北京,100021;中国医学科学院,北京协和医学院,肿瘤医院泌尿外科,北京,100021 |
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| 摘 要： | 前列腺癌（prostate cancer，PC）可以通过多个途径增加患者的骨质丢失，破坏骨完整性。去势治疗（androgen deprivation therapy，ADT）为激素敏感型晚期PC的标准治疗手段，但ADT可以加速患者的骨质丢失，增加骨相关事件（skeletal related events，SREs）的发生率。随机对照临床研究已经证实双磷酸盐类药物可以防治接受ADT的激素敏感型PC患者的骨质丢失，增加其骨密度，减少或延缓SREs的发生，提高患者的生活质量。
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| 关 键 词： | 激素敏感型前列腺癌 去势治疗 双磷酸盐 |
Research advances in the role of bisphosphonates in preventing BMD loss in hormone-sensitive prostate cancer patients undergoing androgen deprivation therapy |
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| Zhao Xin,Ma Jianhui. Research advances in the role of bisphosphonates in preventing BMD loss in hormone-sensitive prostate cancer patients undergoing androgen deprivation therapy[J]. Oncology Progress, 2008, 6(6): 619-624 |
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| Authors: | Zhao Xin Ma Jianhui |
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| Affiliation: | Zhao Xin Ma Jianhui (Departmeat of Urological Surgery, Cancer Hospital and Isntitute, Chinses Academy of Medical Sciences ＆ Peking Union Medical college, Beijing 100021, China) |
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| Abstract: | Prostate cancer （PC） stimulates BMD loss and destroys bone integrity. Androgen deprivation therapy （ADT） is the standard therapy for hormone - sensitive prostate cancer. ADT will accelerate bone loss for patients with PC and raise skeletal - related events （SREs）. Many randomized, placebo - controlled clinical trials confirm that bisphosphonates provide important benefits for patients with hormone-sensitive PC receiving androgen deprivation therapy （ADT）, which can prevent BMD loss, reduce or defer SREs, and improve quality of life of patients with PC. |
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| Keywords: | hormone- sensitive prostate cancer androgen deprivation therapy bisphosphonate |
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