| 麦冬多糖MDG-1对糖尿病小鼠糖耐量及肠道菌群的影响 |
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| 引用本文： | 王令仪,王硕,王源,阮克锋,冯怡.麦冬多糖MDG-1对糖尿病小鼠糖耐量及肠道菌群的影响[J].世界华人消化杂志,2011(19). |
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| 作者姓名： | 王令仪 王硕 王源 阮克锋 冯怡 |
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| 作者单位： | 上海中医药大学;上海中医药大学中药现代制剂技术教育部工程中心; |
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| 基金项目： | 国家自然科学基金资助项目,No.81073065; 上海市教委重点学科基金资助项目,No.J50302;上海市教委预算内科研基金资助项目,No.09JW20; 上海市科委科技基金资助项目,No.11ZR1434400;上海市科委基金资助项目,No.09DZ2292000;No.09DZ1973000; 高等学校博士学科点专项科研基金资助项目,No.2010310,No.7120011~~ |
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| 摘 要： | 目的:研究不同剂量麦冬多糖(MDG-1)对自发性肥胖型二型糖尿病KKay小鼠糖耐量及肠道菌群的影响.方法:正常对照组为周龄9-10wkC57bl/6J小鼠10只,实验组为KKay糖尿病小鼠26只;小鼠9wk开始普通饲料喂养至12wk,随后高脂饲料喂养8wk.12wk时测定随机血糖>13.9mmol/L诊断为糖尿病.小鼠随机分为正常对照组、空白对照组、MDG-175、300mg/kg及罗格列酮组.正常对照组与空白对照组每天灌胃蒸馏水(10mL/kg),罗格列酮组每天灌胃2mg/kg.连续治疗8wk后,观察各组动物的一般情况,测定小鼠0、15、30、60、120min耐糖血糖值,并对各组小鼠肠道菌群进行培养,统计菌群数量.结果:不同剂量的麦冬多糖MDG-1均可在不同程度上改善KKay小鼠的多饮、多食等症状,高剂量组的效果优于低剂量组.给药8wk后,MDG-1低、高剂量均可显著降低糖尿病小鼠的空腹血糖值(P<0.05);各模型组的葡萄糖耐量均不同程度受损,MDG-1300mg/kg和阳性药罗格列酮组糖耐量均有不同程度的改善(P<0.05);糖尿病小鼠肠道内大肠杆菌和链球菌数量显著升高,而乳酸杆菌和双歧杆菌的数量明显...
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| 关 键 词： | 麦冬多糖 糖尿病 KKay小鼠 口服糖耐量实验 肠道菌群 |
Effect of MDG-1 on oral glucose tolerance and intestinal microecological balance in diabetic mice |
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| Ling-Yi Wang.Effect of MDG-1 on oral glucose tolerance and intestinal microecological balance in diabetic mice[J].World Chinese Journal of Digestology,2011(19). |
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| Authors: | Ling-Yi Wang |
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| Institution: | Ling-Yi Wang,Department of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China Shuo Wang,Yuan Wang,Ke-Feng Ruan,Yi Feng,Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,China |
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| Abstract: | AIM:To investigate the effect of different con- centrations of MDG-1,a polysaccharide extracted from Ophiopogon japonicus,on oral glucose tolerance and intestinal microecological balance in KKay mice. METHODS:Twenty-six KKAy diabetic miceand ten 9-10-week-old C57bl/6J mice were used in this study.KKAy diabetic mice were given a normal diet from week 9 to week 12 and then fed a high-fat diet for 8 weeks.Diabetes was diagnosed when random blood glucose level was more than 13.9 mmol/L at week 12.Mice were rand... |
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| Keywords: | MDG-1 Diabetes KKay mice Oral glucose tolerance test Intestinal flora |
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