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| 福康片对大鼠吗啡药代动力学的影响 | |
| 引用本文： | 王玉瑾,员克明,王英元,张加玲,刘燕娥,田树华.福康片对大鼠吗啡药代动力学的影响[J].中国药物依赖性杂志,2001,10(3):179-181. |
| 作者姓名： | 王玉瑾 员克明 王英元 张加玲 刘燕娥 田树华 |
| 作者单位： | 1. 山西医科大学法医学系, 2. 山西医科大学公共卫生学院, 3. 山西职工医学院, 4. 山西医科大学医学实验中心, |
| 基金项目： | 此课题受省自然科学基金资助，基金编号 971052 |
| 摘 要： | 目的··:研究福康片戒毒药物对大鼠吗啡药代动力学的影响。方法··:用放射免疫法 (RIA)测定了大鼠单独皮下注射 (sc)盐酸吗啡 (A组 )和合并灌胃 (ig)福康片 (B组 )后吗啡的血药浓度 ,计算两组吗啡药代动力学参数。结果··:两组吗啡药代动力学模型均符合二室模型一级吸收。B组吗啡血药浓度明显低于A组。合用福康片后 ,大鼠吗啡的t1/2ka由0.078h增加到0.164h ;Cmax由3971.143μg·L -1减少到2248.474μg·L -1 ;AUC由每小时11337.584μg·L-1 减少到8005.219μg·L-1;t1/2β 由4.091h减少到3.615h ;CL由每小时0.529L·kg-1 增加到0.750L·kg-1。结论··:福康片可降低吗啡的吸收速率及血液中的吗啡浓度 |
| 关 键 词： | 吗啡 福康片 药代动力学 放射免疫法 |
| 修稿时间： | 2000年9月7日 |
EFFECTS OF FUKANG TABLETS ON PHARMACOKINETICS OF MORPHINE IN RATS |
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| WANG Yujin,ZHANG Jialing,YUN Keming,LIU Yan'e,TIAN Shuhua,WANG Yingyuan.EFFECTS OF FUKANG TABLETS ON PHARMACOKINETICS OF MORPHINE IN RATS[J].Chinese Journal of Drug Dependence,2001,10(3):179-181. | |
| Authors: | WANG Yujin ZHANG Jialing YUN Keming LIU Yan'e TIAN Shuhua WANG Yingyuan |
| Institution: | WANG Yujin1,ZHANG Jialing2,YUN Keming1,LIU Yan'e3,TIAN Shuhua4,WANG Yingyuan11 |
| Abstract: | Objective: To study the effects of Fukang tablets on the pharmacokinetics of morphine in rats. Method: Using RIA , the concentration of total morphine in serum of rats after pretreatment with morphine (A), and morphine with Fukang tablets (B) was determined. The pharmacokinetic parameters of morphine in A and B groups was calculated. Result: The pharmacokinetics of morphine in Group A and B showed a two-compartment model with first order absorption in the bodies of the rats. In Group B the T1/2ka and CL of morphine were increased, while the Cmax, AUC and T1/2β of morphine were decreased. Conclusion: Fukang tablets can reduce the absorbent rate of morphine and its concentration in serum, while Fukang tablets can also increase the clearance rate of morphine in rats slightly. |
| Keywords: | morphine Fukang tablet pharmacokinetics RIA |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |