Adrenal steroids in post-menopausal women: relation to obesity and to bone mineral content |
| |
| Authors: | S Brody K Carlstr?m A Lagrelius N O Lunell G M?llerstr?m |
| |
| Affiliation: | 1. Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain;2. Child and Adolescent Mental Health Centre, Hospital Sant Joan de Déu Terres de Lleida, Catalonia, Spain;3. Psychiatric Service, Research Institute, Hospital de Santa Creu i Sant Pau, Autonomous University of Barcelona, CIBERSAM, Barcelona, Catalonia, Spain;4. Cognitive Disorders Unit, Hospital Universitari Santa Maria, Neuroscience Clinical Group, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain;5. Laboratory Department, Hospital Universitari Arnau de Vilanova, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain;6. Statistics Unit. Sant Joan de Déu Research Fundation, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Catalonia, Spain;7. Bipolar Disorder Program, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain;1. Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC and Technion-Faculty of Medicine, Haifa, Israel;2. Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Technion-Faculty of Medicine, Haifa, Israel;3. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA;1. Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;2. Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taiwan;3. Department of Chinese Medicine, Tri-Service General Hospital, Taipei, Taiwan;4. School of Public Health, National Defense Medical Center, Taipei, Taiwan;5. Division of Nephrology, Department of Medicine, Shuang Ho Hospital, New Taipei, Taiwan;1. Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9 Street, 02-957 Warsaw, Poland;2. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology CePT, Medical University of Warsaw, Banacha 1B Street, 02-097 Warsaw, Poland |
| |
| Abstract: | Basal levels and ACTH-induced increments of serum 17 alpha-hydroxyprogesterone (170HP), cortisol, 4-androstene-3,17-dione (A-4), dehydroepiandrosterone (DHA), and dehydroepiandrosterone sulphate (DHAS) were related to the degree of obesity and to trabecular bone mineral density in 29 postmenopausal women. The ACTH-induced increment of 170HP (delta 170HP) was negatively correlated to basal DHA and delta DHA. Positive correlations were found between obesity, expressed as Broca's index, and delta DHA and the delta DHA/delta 170HP ratio. Bone mineral density was positively correlated to basal DHAS, delta DHA, delta DHAS and the delta DHA/delta 170HP ratio, and negatively correlated to delta 170HP. DHA and 170HP represent a crossroad in adrenocortical steroid biosynthesis, leading to delta 5-androgens and glucocorticoids as main products. Besides age, obesity may also influence the intra-adrenal distribution between these two main steroidogenic pathways. The results suggest that differences at a very early stage of the adrenal steroidogenesis may influence calcium homeostasis in the post-menopausal woman. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
