Distinguishing features of humoral immunity in BALB/c mice with Rauscher leukemia |
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| Authors: | P. P. Sokolov V. M. Bergol'ts |
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| Affiliation: | (1) Department of Plastic and Reconstructive Surgery, Gaziantep University School of Medicine, Gaziantep, Turkey;(2) Department of Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey;(3) Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey;(4) Department of Pathology, Gaziantep University School of Medicine, Gaziantep, Turkey;(5) Department of Plastic and Reconstructive Surgery, Haydarpasa Numune Training Hospital, Istanbul, Turkey; |
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| Abstract: | Following injection of a relatively small dose of Rauscher virus into BALB/c mice highly sensitive to this virus an increase in the number of B-lymphocytes was found in association with stimulation of synthesis of nonspecific immunoglobulins. After injection of the virus together with Freund's complete adjuvant, normal cells synthesizing antibodies against surface antigen of Rauscher leukemia and leukemic cells with blocking antibodies adsorbed on their surface were present simultaneously in the spleen of the mice in the early stages of development of the disease.Laboratory of Experimental Therapy of Tumors, P. A. Gertsen Moscow Oncologic Research Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Timofeevskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 356–358, March, 1976. |
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| Keywords: | Rauscher leukemia antitumor antibodies |
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