EEG and evoked potential findings in mitochondrial myopathies |
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Authors: | S. J. M. Smith A. E. Harding |
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Affiliation: | (1) Department of Clinical Neurophysiology, The National Hospital for Neurology and Neurosurgery, Queen Square, WClN 3BG London, UK;(2) Department of Clinical Neurology, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, WCIN 313G London, UK |
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Abstract: | Electroencephalograms (EEGs) and evoked potentials (EPs) were studied in 43 patients with mitochondrial myopathies. Abnormalities were found most frequently in patients who presented predominantly or exclusively with central nervous system (CNS) dysfunction (abnormal EEGs in 18 of 21 patients, abnormal EPs in 9 of 11 patients). However, of patients presenting with ocular myopathy or proximal muscle weakness who had little or no CNS involvement clinically, 8 of 22 had abnormal EEGs and 5 of 10 had abnormal EPs, suggesting that electrophysiological tests are of value in demonstrating subclinical CNS disease in mitochondrial myopathy, although the abnormalities are not specific. |
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Keywords: | Electroencephalography Evoked potentials Mitochondrial myopathy |
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