米索前列醇预防剖宫产术后出血的临床观察

目的观察米索前列醇口服给药用于预防剖宫产术后出血的疗效和安全性。方法120例剖宫产术后出血患者随机分为2组,米索前列醇组60例,给予米索前列醇400μg;催产素组60例,给予5%的葡萄糖液500mL加入催产素20U静脉滴注,观察2组患者术后2h的出血量。结果术后2组平均出血量:米索前列醇口服给药组为(87±25)mL,催产素组为(146±36)mL,两组比较差异有统计学意义(P<0.01)。结论米索前列醇口服给药促进子宫收缩作用强于催产素,能较好地预防剖宫产后出血,且用药方便、安全。

Clinical Observation of Misoprostol to Prevent Postpartum Hemorrhage

Objective To observe the efficacy and safety of the oral administration of misoprostol for the prevention of postpartum hemorrhage,Methods 120 cases of postpartum hemorrhage were randomly divided into two groups, the misoprostol group with 60 patients were given misoprostol 400μg; the oxytocin group with 60 patients were given 5% glucose solution 500 mL adding oxytocin 20U intravenous infusion,to observe the bleeding of two groups 2h after operation,Results The average amount of bleeding of two groups 2 h after operation ： oral administration of misoprostol group （ 87 ± 25 ） mL, oxytocin group（ 146 ±36 ）ml,,were statistically significant difference between the two groups（ P 〈0. 01 ）, Conclusion Oral administration of misoprostol for uterine contractions was stronger than oxytocin,can better prevent postparttnn hemorrhage, was convenient and safe,