Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer |
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| Authors: | Decock J Paridaens R Ye S |
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| Institution: | Laboratory for Experimental Oncology (LEO), Department of Oncology, K. U. Leuven, University Hospitals Leuven, Leuven, Belgium;, Multidisciplinary Breast Center (MBC), University Hospitals Leuven, Leuven, Belgium;, and Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, University of London, London, UK |
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| Abstract: | The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer. |
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| Keywords: | breast cancer colorectal cancer lung cancer matrix metalloproteinases polymorphism SNP survival susceptibility |
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