| Bayesian反馈法估算静脉输注伏立康唑的群体药动学参数 |
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| 引用本文： | 孟冬梅,陈文瑛,谢白露,黄珊珊,肖翔林. Bayesian反馈法估算静脉输注伏立康唑的群体药动学参数[J]. 现代食品与药品杂志, 2011, 0(1) |
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| 作者姓名： | 孟冬梅 陈文瑛 谢白露 黄珊珊 肖翔林 |
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| 作者单位： | 广州医学院第一附属医院药学部; |
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| 基金项目： | 广东省医院药学研究基金(编号:2010A19) |
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| 摘 要： | 目的用Bayesian反馈法估算临床患者静脉输注伏立康唑的群体药动学(PPK)参数。方法收集静脉输注给药不同时间后的血样,采用HPLC法测定伏立康唑血药浓度,用Bayesian反馈法估算PPK参数。结果以二室模型拟合伏立康唑的药动学过程,得PPK参数为Vss为(46.58±19.35)L,CL为(4.76±2.64)L/h,k10为(0.187±0.006)h-1k,12为(4.97±0.02)h-1,k21为(0.895±0.308)h-1。结论此PPK模型能够较准确地描述伏立康唑在临床患者静脉输注的药动学特征,其预测能力尚待进一步评估。
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| 关 键 词： | 伏立康唑 群体药动学 Bayesian反馈法 |
Estimating Population Pharmacokinetic Parameters of Voriconazole after Intravenous Infusion by Bayesian Feedback Method |
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| MENG Dong-mei,CHEN Wen-ying,XIE Bai-lu,HUANG Shan-shan,XIAO Xiang-lin. Estimating Population Pharmacokinetic Parameters of Voriconazole after Intravenous Infusion by Bayesian Feedback Method[J]. JOurnal of Modern Food and Pharmaceuticals, 2011, 0(1) |
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| Authors: | MENG Dong-mei CHEN Wen-ying XIE Bai-lu HUANG Shan-shan XIAO Xiang-lin |
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| Affiliation: | MENG Dong-mei,CHEN Wen-ying,XIE Bai-lu,HUANG Shan-shan,XIAO Xiang-lin (The First Affiliated Hospital of Guangzhou Medical College,Department of Pharmacy,Guangzhou,Guangdong 510120,China) |
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| Abstract: | Objective To study the population pharmacokinetics(PPK) of voriconazole in clinical patients after intravenous infusion by Bayesian feedback method.Methods A HPLC method was set up to determine the levels of voriconazole in plasma at different time points after intravenous infusion administration.PPK parameters of voriconazole were estimated by Bayesian feedback method.Results The pharmacokinetic process of voriconazole was described by a linear two-compartment model,the estimated PPK parameters of Vss,CL,k... |
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| Keywords: | voriconazole population pharmacokinetics Bayesian feedback method |
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