| 去甲斑蝥酸钠对肝癌小鼠模型不同时间给药的不良反应比较 |
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| 引用本文： | 王颖彦,罗雪芬,罗懿妮,李彩君,段晓红. 去甲斑蝥酸钠对肝癌小鼠模型不同时间给药的不良反应比较[J]. 现代食品与药品杂志, 2011, 0(3) |
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| 作者姓名： | 王颖彦 罗雪芬 罗懿妮 李彩君 段晓红 |
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| 作者单位： | 广东省中医院药学部; |
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| 基金项目： | 广东省医院药学研究基金(编号:2009A005) |
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| 摘 要： | 目的研究去甲斑蝥酸钠在不同时间段给药对于肝癌小鼠模型的不良反应的差别。方法固定剂量去甲斑蝥酸钠在2 am,10 am,6 pm 3个不同时间连续给药10 d,治疗肝癌荷瘤小鼠,比较各组不良反应的差异。结果去甲斑蝥酸钠不同时间给药,其不良反应有差异,以2 am给药组不良反应最轻,6 pm给药组不良反应最严重。结论去甲斑蝥酸钠治疗肝癌小鼠模型的不良反应与给药时间有一定关系。
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| 关 键 词： | 去甲斑蝥酸钠 肝癌 时间治疗学 不良反应 |
Comparison of Adverse Reaction of Disodium Cantharidinate in Tumor-bearing Mice at Different Administration Time |
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| WANG Ying-yan,LUO Xue-fen,LUO Yi-ni,LI Cai-jun,DUAN Xiao-hong. Comparison of Adverse Reaction of Disodium Cantharidinate in Tumor-bearing Mice at Different Administration Time[J]. JOurnal of Modern Food and Pharmaceuticals, 2011, 0(3) |
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| Authors: | WANG Ying-yan LUO Xue-fen LUO Yi-ni LI Cai-jun DUAN Xiao-hong |
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| Affiliation: | WANG Ying-yan,LUO Xue-fen,LUO Yi-ni,LI Cai-jun,DUAN Xiao-hong (The Pharmaceutical Department of Guangdong Province Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 510120,China) |
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| Abstract: | Objective To evaluate the difference in the adverse reaction of disodium cantharidinate in hepatoma mice model at different administration time.Methods Tumor-bearing mice were administered at different time(2 am,10 am,6 pm) for 10 d by fixed-dose of disodium cantharidinate.The adverse reaction of the 3 groups were compared.Results There was some difference among those 3 groups: the 2 am group had the least adverse reaction,while the 6 pm group had the most serious adverse reaction.Conclusion There is a rela... |
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| Keywords: | disodium cantharidinate hepatoma chronotherapeutics adverse drug reaction |
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