| 慢性阻塞性肺疾病急性加重期患者茶碱血药浓度监测与分析 |
| |
| 引用本文： | 彭晓青,韦炳华. 慢性阻塞性肺疾病急性加重期患者茶碱血药浓度监测与分析[J]. 现代食品与药品杂志, 2011, 0(6) |
| |
| 作者姓名： | 彭晓青 韦炳华 |
| |
| 作者单位： | 广州市第一人民医院;中山大学附属第一医院; |
| |
| 摘 要： | 目的监测慢性阻塞性肺疾病(COPD)急性加重期患者茶碱血药浓度,为临床合理用药提供参考。方法采用高效液相色谱法测定茶碱稳态谷浓度,分析血药浓度与疗效及不良反应的关系。结果在监测的132例患者中有5例发生了不良反应。茶碱血药浓度<5μg/m l的有35例,治疗有效率为85.7%;血药浓度为5~10μg/m l的有64例,治疗有效率为89.1%;血药浓度为10~15μg/m l的有22例,治疗有效率为72.7%;血药浓度为15~20μg/m l的有6例,治疗有效率为83.3%;血药浓度>20μg/m l的有5例,治疗有效率为80.0%。结论低浓度茶碱(<10μg/m l)能较好地控制COPD急性加重期症状。
|
| 关 键 词： | 慢性阻塞性肺疾病 急性加重期 茶碱 血药浓度 |
Monitoring and Analysis of Theophylline Blood Concentration in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| |
| PENG Xiao-qing,WEI Bing-hua. Monitoring and Analysis of Theophylline Blood Concentration in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. JOurnal of Modern Food and Pharmaceuticals, 2011, 0(6) |
| |
| Authors: | PENG Xiao-qing WEI Bing-hua |
| |
| Affiliation: | PENG Xiao-qing1,WEI Bing-hua2(1.Guangzhou First Municipal People's Hospital,Guangzhou,Guangdong 510180,China,2.The First Affiliated Hospital,Sun Yat-Sen University,Guangdong 510080,China) |
| |
| Abstract: | Objective To explore the blood concentration of theophylline in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD),and to provide reference for clinical medication.Methods The steady state trough concentration of theophylline was determined by high performance liquid chromatography.The relationships among the blood concentration,the effect and the adverse drug reaction were analyzed.Results There had 5 adverse drug reactions in 132 cases.The results of blood concentration of the... |
| |
| Keywords: | chronic obstructive pulmonary disease acute exacerbation theophylline blood concentration |
| 本文献已被 CNKI 等数据库收录！ |
|
