| 动脉粥状硬化与血清中磷脂酰胆碱特异性磷脂酶C活性的相关性研究 |
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| 引用本文： | 赵阳,张立燕,丁丽娜,王楠,金星,苗俊英.动脉粥状硬化与血清中磷脂酰胆碱特异性磷脂酶C活性的相关性研究[J].生物医学工程研究,2006,25(2):89-92. |
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| 作者姓名： | 赵阳 张立燕 丁丽娜 王楠 金星 苗俊英 |
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| 作者单位： | 1. 山东大学生命科学学院发育生物学研究所,山东,济南,250100
2. 山东省立医院血管外科,山东,济南,250021 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 炎症在动脉粥状硬化(AS)形成过程中起关键作用,PC-PLC在炎症反应中扮演重要角色。为探讨PC-PLC活性与动脉粥样硬化的关系,本研究建立了动脉粥状硬化家兔模型,并用解毒活血颗粒灌胃,分别获得正常家兔血清、造模家兔血清和药物家兔血清,检测其中PC-PLC的活性。结果表明,造模组中钙离子依赖性和非钙离子依赖性两种PC-PLC活性均明显高于正常组,而加药组中这两种PC-PLC活性受到显著抑制。说明伴随动脉粥样硬化的发生,PC-PLC活性明显升高,而活血解毒颗粒能减轻动脉粥样硬化的程度,同时能显著抑制PC-PLC活性。
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| 关 键 词： | 炎症 动脉粥状硬化 血清 磷脂酰胆碱特异性磷脂酶C 酶活 |
| 文章编号： | 1672-6278（2006）02-0089-04 |
| 收稿时间： | 2006-03-05 |
| 修稿时间： | 2006年3月5日 |
The Relationship between Atherosclerosis and Phosphatitylcholine Specific Phospholipase C Activity in Serum |
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| ZHAO Yang,ZHANG Li-yan,DING Li-na,WANG Nan,JIN Xing,MIAO Jun-ying.The Relationship between Atherosclerosis and Phosphatitylcholine Specific Phospholipase C Activity in Serum[J].Journal Of Blomedical Englneerlng Research,2006,25(2):89-92. |
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| Authors: | ZHAO Yang ZHANG Li-yan DING Li-na WANG Nan JIN Xing MIAO Jun-ying |
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| Abstract: | Inflammation plays an important role in atherosclerosis(AS).PC-PLC is a key factor in inflammation.To study the relationship between PC-PLC and AS,the models of AS in rabbit were developed and PC-PLC activity was assayed in normal,AS and therapeutic groups.We found that comparing with normal group,Ca~(2 )-dependent and Ca~(2 )-independent PC-PLC activity in AS group increased,and comparing with AS group,the two kinds of PC-PLC activity in therapeutic group were inhibited.The result show that PC-PLC may be involved in atherosclerosis. |
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| Keywords: | Inflammation Atherosclerosis Serum Phosphatitylcholine specific phospholipase C Enzyme activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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