| 系统性红斑狼疮患者血管内皮细胞损伤标志物检测及其临床意义 |
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| 引用本文： | 张信强,刘晓华,柯瑶,王嫱,梅焕平.系统性红斑狼疮患者血管内皮细胞损伤标志物检测及其临床意义[J].山东医药,2005,45(16):11-12. |
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| 作者姓名： | 张信强 刘晓华 柯瑶 王嫱 梅焕平 |
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| 作者单位： | 南京医科大学第一附属医院,江苏南京,210029 |
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| 基金项目： | 江苏省教委基金资助项目(No.OOKJD320027) |
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| 摘 要： | 目的探讨血管内皮细胞损伤与系统性红斑狼疮(SLE)疾病活动、肾脏损伤的关系。方法应用酶联免疫吸附试验(ELISA)检测31例SLE患者和10例健康对照者血浆可溶性血栓调节蛋白(sTM)、血管假性血友病因子(vWF)水平。结果SLE组血浆sTM、vWF水平明显高于对照组；SLE组血浆sTM、vWF水平均与疾病活动指数(SLEDAI)呈显著正相关，与24小时尿蛋白定量呈正相关。结论血管内皮损伤可能在SLE发病机制中起重要作用，血浆sTM、vWF水平可作为判断SLE疾病活动性及肾脏损伤程度的指标。
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| 关 键 词： | 血管内皮细胞损伤 系统性红斑狼疮患者 标志物检测 酶联免疫吸附试验（ELISA） 临床意义 血浆可溶性血栓调节蛋白 血管假性血友病因子 疾病活动指数 血管内皮损伤 肾脏损伤程度 SLE患者 尿蛋白定量 疾病活动性 sTM vWF 方法应用 |
Detection of markers of endothelial cell injury in SLE patients and its clinical significance |
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| Zhang Xinqiang,Liu Xiaohua,Ke Yao,et al.Detection of markers of endothelial cell injury in SLE patients and its clinical significance[J].Shandong Medical Journal,2005,45(16):11-12. |
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| Authors: | Zhang Xinqiang Liu Xiaohua Ke Yao |
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| Abstract: | Objective To explore the relationship between endothelial cell injury and disease activity and renal damnification in systemic lupus erythematosuss(SLE) patients.Metholds The plasma levels of soluble thrombomodulin (sTM) and von Willebrand factor (vWF) were determined with enzyme-linked immunosorbent assay(ELISA) in 31 SLE patients and 10 healthy subjects.Results The plasma levels of sTM and vWF in 31 SLE patients were significantly higher than those in 10 healthy subjects.The plasma levels of sTM and vWF showed positive significant correlation with disease activity and the quantity of 24 hour urine protein in SLE patients.Conclusion The vascular endothelium injury may play an important role in the pathological mechanism of SLE,markers of endothelial cell injury may be used as index of the disease activity and renal damnification. |
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| Keywords: | Systemic lupus erythematosus Endothelial cell Thrombomodulin von Willebrand factor |
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