利培酮对精神分裂症患者社会功能的研究

目的:比较利培酮与氯氮平治疗的精神分裂症患者出院后社会功能状况,方法:随机抽取30例服用利培酮,30例服用氯氮平的精神分裂症患者,用阳性症状和阴性症状量表(PANSS), 明精神病评定量表(BPRS),不良反应症状量表(TESS)评定.出院后半年用社会功能缺陷量表(SDSS)评定,并与某些因素进行相关分析及多元逐步回归分析.结果:半年随访发现,服用利培酮的精神分裂症患者在职业工作,婚姻职能,父母职能和社会退缩等社会功能方面明显好于氯氮平,多元逐步回归分析显示,影响社会功能的因素为经济损失多,男性,不能积极参加组织活动,不能与他人和睦相处,BPRS评分高者社会功能差,服用氯氮平的比利培酮差.结论:利培酮和氯氮平相比,治疗的优势主要不在于副反应方面,而在于能较好地改善社会功能.

A comparative study of social function in schizophrenic patients treated with risperidone or clozapine

Objective:To compare the social function in schizophrenic patients treated with risperidone or clozapine. Method:Sixty patients with the diagnosis of schizophrenia were randomly entered into risperidone group (n=30) and clozapine group (n=30).The therapeutic response and side effects were evaluated with the positive and negative symptom scale (PANSS) and the treatment emergent symptom scale (TESS).All patients were assessed with the social disability screening schedule (SDSS) at the sixth month after discharge. Results:It was found that the social functions (including profession,marriage,parental responsibility,et al) were significantly better in risperidone group than in clozapine group.With multiple regression analysis,the main associated factors of impaired social function were high impaired scores of BPRS,male,bad personnel relationship and using clozapine. Conclusion:Risperidone is superior clozapine to improve the condition of social function in schizophrenic patients.