通心络对高血压病肥胖患者左心室舒张功能的影响

目的观察通心络对高血压病肥胖患者左心室舒张功能的影响。方法58例高血压肥胖患者分为观察组(n=30)和对照组(n=28),对照组每日晨口服非洛地平5 mg,每周随访1次,若舒张压≤12.0 kPa,则维持原剂量,若舒张压>12.0 kPa,则隔日增加剂量1次,每次增加5 mg,每次最大剂量为20 mg,同时接受行为干预(限盐、忌酒、适量运动等),总疗程3个月。治疗组在对照组治疗的基础上每日加用通心络胶囊6粒,分3次口服,总疗程3个月。检测2组患者治疗前后二尖瓣舒张早期流速峰值(EPFV)、晚期流速峰值(APFV)及峰值比(E/A),评价左心室舒张功能,并检测血糖、血脂、胰岛素等生化指标评价对胰岛素的敏感性。结果观察组和对照组治疗后HDLc/LDLc、EPFV、E/A较治疗前增高(P<0.01,P<0.05),APFV、胰岛素敏感指数(ISI)绝对值、TG较治疗前下降(P<0.05)。治疗后治疗组的EPFV、E/A、HDLc/LDLc较对照组升高(P<0.01),APFV、ISI绝对值、TG较对照组显著下降(P<0.01)。结论通心络能调节脂质代谢、降低胰岛素抵抗、改善高血压肥胖患者的左心室舒张功能。

Effects of Tonxinluo on the left ventricular diastolic function in patients with hypertension and obesity

Objective To observe the effects of Tonxinluo on the left ventricular diastolic function in patient with hypertension and obesity. Methods Fifty-eight cases were divided into observation group （ n = 30） and control group（ n = 28 ）. Oral felodipine 5mg daily morning in the control group, every week a follow-up, if DBP ≤ 12.0 kPa, while maintaining the original dose, DBP 〉 12.0 kPa,then increase the dose of 5 mg, and the largest dose of 20 rag,at the same time the behavioral intervention（ salt restriction,Jijiu,regular exercise, etc. ）were given, with a total course of treatment for three months. Based on these, six Tongxinluo Capsules were given every day in the treatment group with a total, course of treatment for 3 months. EPFV, APFV and E/A were detected pre and post-treatment and compared between two groups, left ventricular function was evaluated, and blood sugar,blood lipid,insulin and other biochemical parameter sensitivity to insulin were tested. Results EPFV, E/A, HDLc/LDLc after treatment in Observation and control groups were higher than that before treatment（ P 〈 0.01, P 〈 0. 05 ）, but APFV,ISI and TG were lower than before treatment （ P 〈 0. 05 ）. After treatment, the EPFV, E / A and HDLc / LDLc in treatment group were higher than control group （ P 〈 0.01 ）, APFV, ISI, TG were lower than control group （ P 〈 0. 01 ）. Conclusion Tonxinluo can regulate the lipid metablolism, reduce insulin resistance and improve the left ventricular diastolic function in pations with hypertension and obesity.