In vivo and in vitro effect of chelating agents on drug metabolizing enzymes of the rat |
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Authors: | R.R. Dalvi C. McGowan A. Ademoyero |
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Affiliation: | Toxicology Laboratory, Department of Physiology and Pharmacology, School of Veterinary Medicine, Tuskegee Institute, Tuskegee, Alabama 36088 U.S.A. |
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Abstract: | Rats given calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA), diethylenetriaminepentaacetic acid (DTPA), dimercaprol, p-aminosalicylic acid (PAS), or d-penicillamine (penicillamine) i.p. for 7 successive days showed a significant decrease in the activity of hepatic microsomal benzphetamine N-demethylase. There was no appreciable change in the microsomal cytochrome P-450 concentration. In vitro incubation of the chelating drugs with liver microsomes isolated from rats pre-treated with phenobarbital caused no significant loss of the hemoprotein. The decreased rate of benzphetamine metabolism in microsomal preparations from rats, pretreated with the chelating drugs, may be attributed partly to hepatic depletion of essential trace elements by the chelating drugs. |
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Keywords: | DMSO dimethyl sulfoxide DTPA diethylenetriaminepentaacetic acid PAS |
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