Enhanced ratio of linoleic acid to arachidonic acid in erythrocyte phosphatidylcholine in rats during withdrawal from ethanol |
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Authors: | G.Ananda Rao Steven C. Goheen Marcia Manix Edward C. Larkin |
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Affiliation: | Hematology Research Laboratory, Veterans Administration Medical Center, 150 Muir Road, Martinez, CA 94653 U.S.A. |
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Abstract: | Male Sprague-Dawley rats were pair-fed for 8 weeks either an alcohol diet or a control diet made isocaloric with dextrose. Those on the alcohol diet were then fed the control diet for 3 days and both groups were killed. Analysis of the fatty acid composition of the various blood lipids showed that the relative level of 18:2 to 20:4 was significantly greater in the phosphatidylcholine fraction from erythrocytes of rats withdrawn from alcohol as compared to that from control animals. It has been suggested that in alcohol-fed animals the hepatic capacity to produce 20:4 from 18:2 is reduced. Therefore the increase in the ratio of 18:2/20:4 in erythrocyte phosphatidylcholine could serve as an index to detect the liver malfunction and to confirm recent chronic alcohol consumption. |
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Keywords: | TLC thin-layer chromatography |
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