进行性核上性麻痹患者脑部葡萄糖代谢特征分析

目的：利用^18F-脱氧葡萄糖（^18F-FDG）正电子发射断层扫描成像（PET）分析进行性核上性麻痹（PSP）患者脑部葡萄糖代谢特征。方法：7例临床确诊的PSP患者（PSP组）和14例年龄匹配的健康对照者（对照组）行静息状态下^F—FDGPET脑成像，将两组的PET图像分别进行统计参数图（SPM）及尺度子轮廓模型／主要成分分析（SSM／PCA）研究，获得PSP患者脑部葡萄糖异常代谢图像并建立PSP脑代谢网络模式（PSPRP）。结果：SPM分析显示，与对照组比较，PSP组双侧内侧前额叶、腹外侧前额叶、尾状核、丘脑和中脑的葡萄糖代谢降低，双侧中央前回、顶上小叶、顶下小叶葡萄糖代谢增高。SSM／PCA分析显示PSPRP的特征表现为双侧内侧前额叶、腹外侧前额叶、尾状核、丘脑和中脑的葡萄糖代谢显著减低，而双侧顶叶代谢显著增高。PSP组的PSPRP表达值（1．711±1．218）明显高于对照组（0．043±O．496，t=-5．379，P=0．001）。结论：基于18F-FDGPET显像得到的脑部异常葡萄糖代谢特征可以有效鉴男IJPSP患者和健康对照者。

Characteristics of Cerebral Glucose Metabolism in Patients with Progressive Supranuclear Palsy

T Aim. To identify abnormal cerebral glucose metabolism characteristics in patients with progressive supranuclear palsy（PSP） with^18F-fluorodeoxyglucose（^18F-FDG） positron emission tomography （PET） imaging. Methods： 7 patients with PSP and 14 age-matched normal individuals were studied with resting-state brain JSF-FDG PET imaging. Statistical Parametric Mapping（SPM） and Scaled Subprofile Model/ Principal Component Analysis（SSM/PCA） were used to get the characteristics including PSP-related pattern （PSPRP）. Results： The features of brain glucose metabolism by SPM analysis in the PSP cohort were demonstrated as bilaterally decreased metabolism in the medial prefromal cortex, the ventrolateral prefrontal cortex, the caudate, the thalamus and the midbrain, and increased metabolism in the precentral gyrus, the superior parietal lobule and the inferior parietal lobule. PSPRP was characterized by covarying metabolic decreases in the medial prefrontal cortex, the ventrolateral prefrontal cortex, the caudate, the thalamus and the midbrain, and was associated with increase in the bilateral parietal cortex. PSPRP values for PSP patients （1.711 ± 1.218, P=0.001） were elevated relative to those for healthy controls（0.043 ± 0.496, t=-5.379, P= 0.001）. Conclusion： Cerebral glucose metabolism features of PSP based on ^18F-FDG PET imaging contribute to differential diagnosis between PSP patients and normal individuals.