秣醉药物对单肺通气时缺氧性肺血管收缩影响的研究进展

缺氧性肺血管收缩（hypoxicpuImonaryvasoconstriction，HPV）是肺血管发生快速、可逆的收缩反应，它可使低氧肺泡的血流减少而使氧合更充分的血液转移到通气较好的肺，减少无效通气和功能性分流，减少低氧血症的发生。本文将对单肺通气时影响缺氧性肺血管收缩的代表性麻醉药物以及相关研究进展进行综述。

The Progress＇ of Effects of Narc.otic＇s on Hypoxic Pulmonary Vasoconstriction during One-Lung Ventilation

Ozone therapy is a common minimally invasive therapeutic method in treating protrusion of lumber intervertebral disc which has acquired favorable therapeutic effects, and it includes intradiscal, paravertebral and intraforaminal injection. It has been shown that ozone has oxidative effect on normal intervertebral disc and cells. The mechanisms of ozone therapy involve direct oxidative action to nucleus pulposus, modulating oxidative stress, regulation of immune system, activating the descending antinociceptive system and increasing oxygen supplies which decrease the production of inflammatory mediators. However, some of these mechanisms have not been well understood. So a quantity of clinical evidence and the well know of the mechanisms of ozone will be of vital importance to the better clinical application of ozone.