乳酸镁对心肌再灌注损伤时血小板聚集的影响

目的：观察乳酸镁对心肌缺血－再灌注损伤过程中血小板聚集的影响，探讨乳酸镁心肌保护作用的机理。方法：利用整体大鼠急性心肌缺血再灌注模型，结扎冠脉左室支40min，再灌注40min,取血测定血小板聚集率，计算聚集抑制率。结果：再灌注前给乳酸镁对缺血再灌注时的血小板聚集有抑制作用，110mg/kg组较150mg/kg组抑制血小板聚集作用更明显。结论：乳酸镁对心肌再灌注损伤的保护作用与其防止血小板聚集有关。

The Cardioprotective Effect of Magnesium Lactate on Platelet Aggregation during Myocardial Ischemia Reperfusion Injury

Objective The effect of magnesium lactate as a cardioprotective agent on platelet aggregation induced by acute myocardial ischemia and reperfusion injury was investigated in anaesthetized rats.Methods Occlusion of anterior descending branch of left coronary artery(LAD)was performed for 40 minutes and followed by 40 minutes reperfusion Test the AGG(M),caculate the ratio of ADP-induced platelet inhibition.Results Administration of 110mg/kg of Magnesium lactate,10 minutes before reperfusion was more effective than administration of 150mg/kg of Magnesium lactate in inhibiting rate platelet aggregation induced by ADP.Conclusion Magnesium lactate has protective effects on myocardial ischemia reperfusion injury.The protective effect may be related to its action of inhibiting the platelet aggregation induced by ADP.