D-serine in the developing human central nervous system |
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Authors: | Fuchs Sabine A Dorland Lambertus de Sain-van der Velden Monique G Hendriks Margriet Klomp Leo W J Berger Ruud de Koning Tom J |
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Affiliation: | Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. s.fuchs@umcutrecht.nl |
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Abstract: | To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development. |
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