| 热休克蛋白60抗体与冠心病的关系研究 |
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| 引用本文： | 张晓敏,何美安,程龙献,周莉,曾和松,陈樱,田昌俊,邬堂春.热休克蛋白60抗体与冠心病的关系研究[J].劳动医学,2009(1):16-19. |
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| 作者姓名： | 张晓敏 何美安 程龙献 周莉 曾和松 陈樱 田昌俊 邬堂春 |
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| 作者单位： | 华中科技大学同济医学院公共卫生学院环境与健康教育部重点实验室;华中科技大学协和医院;华中科技大学同济医院; |
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| 基金项目： | 国家自然科学基金资助(编号:30430590,30128021) |
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| 摘 要： | 目的]探讨热休克蛋白60（HSP60）抗体水平与冠心病（CHD）的关系。方法]采用病例．对照研究方法，选取未治疗过的CHD患者615例为病例组，以同性别、年龄（土1岁）进行1：1匹配，共选取615例无CHD且无重要脏器疾病者为对照组。采用间接酶联免疫吸附法测定血浆HSP60抗体水平，Logistic回归分析HSP60抗体与CHD的关系。结果]CHD组的HSP60抗体水平明显高于对照组，差异有统计学意义（P=0．000）。在校正了传统的危险因素后，与下四分位数HSP60抗体组相比，上四分位数HSP60抗体组发生CHD的危险度是其2.48（95％CI：1．78～3．46）倍；多支病变的危险度是其3．60（95％CI：1．32．9．83）倍，差异有统计学意义。结论]HSP60抗体与CHD的发病风险及其严重程度相关，提示HSP60抗体在CHD的发生发展中可能发挥某些作用。
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| 关 键 词： | 热休克蛋白60 抗体 冠心病 |
A Study on Association between Antibody to Heat Shock Protein 60 and Risk of Coronary Heart Disease |
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| ZHANG Xiao-min,HE Mei-an,CHENG Long-xian,ZHOU Li,ZENG He-song,CHEN Ying,TIAN Chang-jun,WU Tang-chun.A Study on Association between Antibody to Heat Shock Protein 60 and Risk of Coronary Heart Disease[J].Journal of Labour Medicine,2009(1):16-19. |
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| Authors: | ZHANG Xiao-min HE Mei-an CHENG Long-xian ZHOU Li ZENG He-song CHEN Ying TIAN Chang-jun WU Tang-chun |
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| Institution: | 1.Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health;Wuhan;Hubei 430030;China;2.Department of Cardiology;Union Hospital;3.Department of Cardiology;Tongji Hospital;Tongji Medical College;Huazhong University of Science and Technology;China |
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| Abstract: | Objective]To investigate the relationship between the level of antibody to heat shock protein 60(anti-HSP60) and risk,as well as severity of coronary heart disease(CHD)in Chinese population.Methods]615 CHD patients without treatment and 615 age-and sex-frequency matched controls were recruited in the case-control study.The level of anti-HSP60 in plasma were measured using enzyme-linked immunosorbent assay.Logistic regression model was used to analyze the relationship between anti-HSP60 level and CHD risk.... |
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| Keywords: | sheat shock protein 60 antibody coronary heart disease |
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