姜黄素改善非酒精性脂肪性肝病的研究进展

非酒精性脂肪性肝病(Non-alcoholic fatty liver disease，NAFLD)是目前全球最常见的慢性肝病之一，发病率呈现不断上升的趋势。姜黄素是从姜科植物姜黄中提取的具有多种生物活性的多酚类化合物。大量研究证实姜黄素具有良好的降脂、抗炎、抗氧化、抗纤维化等药理活性，并且对NAFLD、肥胖、胰岛素抵抗等多种代谢性疾病疗效显著，因而有着重要的临床价值和广阔的应用前景。就姜黄素治疗NAFLD的药理学作用及相关机制研究进行综述，旨在为姜黄素治疗代谢性疾病的研究提供参考，并推广其预防和改善NAFLD以及其它脂质代谢紊乱相关疾病可能的临床应用。 

Research Progress of Curcumin for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in the world with rising incidence. Curcumin, a polyphenolic compound extracted from turmeric, a plant of Zingiberaceae, has very extensive biological activities. A large number of studies have confirmed that curcumin showed good antiatheroscloresis, anti-oxidation, anti-inflammation, anti-fibrosis and other pharmacological activities. It has a significant effect on a variety of metabolic diseases such as NAFLD, obesity, insulin resistance and so on. Therefore, curcumin has important clinical value and broad application prospects. This paper summarized the potential mechanisms of curcumin in the treatment of NAFLD, aiming to provide reference for the treatment of metabolic diseases, and to promote its possible clinical application in the prevention and treatment of NAFLD and other lipid metabolism related diseases.