Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy. |
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| Authors: | M. P rez, J. M. Valpuesta, E. M. de Garcini, C. Quintana, M. Arrasate, J. L. L pez Carrascosa, A. R bano, J. Garcí a de Y benes, J. Avila |
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| Affiliation: | M. Pérez, J. M. Valpuesta, E. M. de Garcini, C. Quintana, M. Arrasate, J. L. López Carrascosa, A. Rábano, J. García de Yébenes, and J. Avila |
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| Abstract: | ![]()
Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP. |
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