| 纤维联接蛋白在乙型病毒性肝炎肝组织内的表达 |
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| 引用本文： | 李明.纤维联接蛋白在乙型病毒性肝炎肝组织内的表达[J].华中科技大学学报(医学版),1993(5). |
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| 作者姓名： | 李明 |
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| 作者单位： | 同济医科大学基础医学院病理学教研室 武汉 |
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| 摘 要： | 用兔抗人纤维联接蛋白(FN)抗体经PAP法染色,应用形态计量学方法对45例乙型病毒性肝炎患者肝组织内FN的分布进行研究。结果表明,除慢性持续性肝炎组外,各型肝炎组肝小叶内FN 含量均有所减少,其程度与肝炎时肝细胞变性、坏死程度相关。然而慢性持续性肝炎组、慢性活动性肝炎组及亚急性重型肝炎组门管区内FN 含量与正常肝组比较均有所增多。FN 沉积的增多与该区域内纤维结缔组织的增生相平行。
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| 关 键 词： | 纤维联接蛋白 乙型肝炎 免疫组织化学 形态计量学 |
Expression of Fibronectin in Liver Tissue in Patients with Viral Hepatitis B |
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| Li Ming.Expression of Fibronectin in Liver Tissue in Patients with Viral Hepatitis B[J].Journal of Huazhong University of Science and Technology(Health Sciences),1993(5). |
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| Authors: | Li Ming |
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| Institution: | Li MingDepartment of Pathology,School of Medical Sciences,Tongji Medical University,Wuhan 430030 |
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| Abstract: | Distribution of fibronectin (FN) in liver tissue in 45 patients with viral hepatitis B was studied by using rabbit anti-human FN monoclonal antibody, PAP method, and morphometry. The results showed that the FN content in liver lobules in almost all types of viral hepatitis decreased, except chronic persistent hepatitis, and it was related to the degree of degeneration and necrosis of the liver cells during hepatitis. On the contrary, however, the FN content in portal triads in the chronic persistent hepatitis, chronic active hepatitis and subacute severe hepatitis groups increased in comparison with that of the normal liver group. The increased FN deposit in portal triads corresponded closely to the increased proliferation of the connective tissue in that areas. |
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| Keywords: | fibronectin viral hepatitis B immunohistochemistry morphometry |
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