Patterns of food allergen-specific cytokine production by T lymphocytes of children with multiple allergies |
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| Authors: | T. H. Scott-Taylor,J. B. Hourihane &dagger ,J. Harper&Dagger , S. Strobel § |
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| Affiliation: | Division of Immunobiology, Institute of Child Health, London, UK. t.scott-taylor@medsch.ucl.ac.uk |
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| Abstract: | BACKGROUND: The contribution of different T cell subsets to the overall measured cytokine response to food allergens is largely unexplored. METHOD: The patterns of cytokine production of peripheral blood-derived T cells after allergen stimulation were studied in 22 children with multiple food allergies and in 20 non-allergic children as controls, using flow cytometry. RESULTS: Proportions of T cells of food-sensitized children spontaneously secreting IFN-gamma and IL-10 (without antigen stimulation) were lower than non-atopic children and adult controls (P
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| Keywords: | allergy CD45 RO IFN-γ IL-2 IL-4 IL-10 T cells |
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