| 霉酚酸酯处理的供者树突状细胞在诱导同种小鼠心脏移植耐受中的作用 |
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| 引用本文： | 韩丛辉,张明,王寅,殷明,闵志廉.霉酚酸酯处理的供者树突状细胞在诱导同种小鼠心脏移植耐受中的作用[J].中华器官移植杂志,2003,24(3):166-168. |
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| 作者姓名： | 韩丛辉 张明 王寅 殷明 闵志廉 |
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| 作者单位： | 1. 200003,上海,第二军医大学附属长征医院肾脏移植中心全军泌尿外科中心
2. 第二军医大学药学院药理教研室 |
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| 摘 要： | 目的 探讨霉酚酸酪(MMF)处理的供音来源的树突状细胞(DC)在诱导免疫耐受中的作用。方法 同种小鼠异位心脏移植前经尾静脉注射培养7d的供音源未成熟DC或培养的同时以MMF处理的供者未成熟DC，观察移植心脏存活时间以及受鼠血清中TH1和TH2细胞因子的变化。结果 接受未成熟DC回输的受者移植心脏存活期较单纯移植组显著延长，而以MMF处理未成熟DC可使移植物的存活时间得到进一步延长，并且显著抑制了TH1细胞因子的产生。结论 MMF对比的功能成熟有显著的抑制作用，MMF处理的DC能够诱导针对移植供者的特异性免疫耐受。
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| 关 键 词： | 异位心脏移植术 霉酚酸酯 树突状细胞 免疫耐受 T淋巴细胞 |
| 修稿时间： | 2001年3月19日 |
Pretreatment of donor dendritic cells with MMF to induce tolerance in allograft recipients |
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| HAN Cong hui ,ZHANG Ming,WANG Yin,et al..Pretreatment of donor dendritic cells with MMF to induce tolerance in allograft recipients[J].Chinese Journal of Organ Transplantation,2003,24(3):166-168. |
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| Authors: | HAN Cong hui ZHANG Ming WANG Yin |
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| Institution: | HAN Cong hui *,ZHANG Ming,WANG Yin,et al. *Center of Kidney Transplantation,Changzheng Hospital,The Second Military Medical University of PLA,Shanghai 200003,China |
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| Abstract: | Objective To explore the effects of donor dendritic cells treated with MMF in tolerance induction in allograft recipients.Methods Twenty four C57BL/6 mice were divided into three groups ( n =8 in each): group A accepted hearts from BALB/c donors; group B was infused with immature dendritic cells derived from BALB/c donors 7 days before transplant; group C was the same as that in group B except the dendritic cells were treated with MMF during culture. Results Donor hearts functioned longer in the group B than in the group A, while the group C showed the longest survival time with a most suppressed Th1 cytokine profile.Conclusion MMF has a suppressive effect on the maturation and function of dendri tic cells, which leads to a donor specific tolerance in transplant recipients. |
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| Keywords: | Mycophenolate mofetil Dendritic cells Immune tolerance |
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