醒脑静治疗急性酒精中毒的临床和实验研究

探讨中药醒脑静注射液治疗急性酒精中毒的机理。方法；选择单纯酒厥急诊患者及实验家兔模型，静脉用醒脑静注射液治疗，用药前及清醒后分别测定血浆β－内啡肽，氧自由基，超氧化物歧化酶。结果；醒脑静在促醒酒厥家兔模型及患者的同时，β－内啡肽从酒厥时明显高于健康人，降低至接近正常水平。

Clinical and Experimental Study on Treatment of Acute Alcohol Intoxication with Xingnaojing Injection

OBJECTIVE: To study the therapeutical mechanism of traditional Chinese medicine Xingnaojing injection (XNJI) for acute alcohol intoxication. METHODS: XNJI was used in treating the experimental model rabbits (n = 26) and the patients (n = 8) admitted to the emergency department with acute alcoholism. Before and after the treatment, beta-EP, superoxide anion (free radicals) and SOD were measured. RESULTS: XNJI could enhance the regaining consciousness of rabbits and patients, simultaneously reduce the concentration of beta-EP in plasma to the normal level (drunk rabbits 127.09 +/- 13.67 ng/L, normal rabbits 41.48 +/- 7.46 ng/L. P < 0.01, drunk patients 292.97 +/- 14.85 ng/L, normal people 221.60 +/- 15.95 ng/L, P < 0.01). The concentration change of superoxide anion (free radicals) in plasma of rabbits and patients was similar to beta-EP (drunk rabbits 313.39 +/- 15.64 u/L, normal rabbits 254.27 +/- 21.71 u/L, P < 0.01; drunk patients 278.47 +/- 11.48 u/L, normal people 159.92 +/- 11.51 u/L, P < 0.01), and SOD was inversely changed (drunk rabbits 53.57 +/- 6.48%, normal rabbits 77.18 +/- 7.89%, P < 0.01; drunk patients 43.76 +/- 7.84%, normal people 82.53 +/- 4.33%, P < 0.01). CONCLUSIONS: XNJI is similar to Naloxone in pharmacologic action. And it is an effective antioxidant. It can be used for treating alcoholism.