肺动脉高压相关因子的研究进展

肺动脉高压是不同病因导致的、以肺动脉压力和肺血管阻力升高为特点的一组病理生理综合征.其复杂的发病机制仍未完全明了,但近年来随着人们对肺动脉高压发病机制认识的不断深入,发现一些使肺血管舒缩及重塑的因子在肺动脉高压形成过程中发挥着极其重要的作用.本文主要阐述低氧诱导因子1、尾加压素Ⅱ、降钙素基因相关肽、血管生成素1在肺动脉高压中的作用机制.

Recent advances in research on factors related to pulmonary hypertension

Pulmonary hypertension is a group of physiopathologic syndromes that are induced by different diseases and are featured with high pulmonary artery pressure and higher resistance of pulmonary vasculature. The pathogenic mechanism of pulmonary hypertension is still not completely known. But recently,with the advanced understanding of the mechanism of pulmonary hypertension, the studies at the molecular level show that some factors which induce pulmonary vasodilation, vasoconstriction and remodeling play a very important role during the process of the formation of pulmonary hypertension. This article mainly reviews the mechanism of hypoxia-inducible factor-1, urotensin Ⅱ, calcitonin gene related peptide, angiopoietin-1 during the process of the formation of pulmonary hypertension.