MUC1、MUC2与Met在下咽癌中的表达及其临床意义

目的:探讨MUC1、MUC2与Met在下咽癌中的表达及其临床意义。方法:采用免疫组化方法检测了59例下咽癌MUC1、MUC2和Met的表达。结果:59例下咽癌中MUC1高表达率为66.1%(39/59),MUC2高表达率为61.0%(36/59),Met高表达率为61.0%(36/59);MUC1低表达率为33.9%(20/59),MUC2低表达率39.0%(23/59),Met低表达率39.0%(23/59)。MUC1和MUC2均与Met的表达高低显著相关(P<0.01),MUC1与MUC2的表达不相关(P>0.05)。此三项指标的高表达组淋巴结转移的发生率均显著高于低表达组(P<0.01),而在肿瘤的不同分化程度组间差异无显著性(P>0.05)。MUC2蛋白的表达在肿瘤的不同T分级组间差异有显著性(P<0.01)。MUC1、MUC2、Met高表达组生存率均显著低于低表达组(P<0.01)。结论:MUC1、MUC2、Met的表达参与了下咽癌的发生发展,3项指标联合检测可更好地预测下咽癌的预后。

Expression of MUC 1,MUC2 and Met in hypopharyngeal carcinoma and their clinical significance

Objective: To explore the relationship between the expression of MUC1,MUC2 and Met in hypopharyngeal carcinoma and clinicopathological parameters and their clinical significance. Methods: The expression of MUC1, MUC2 and Met in 59 hypopharyngeal carcinoma were detected by S-P immunohistochemical technique. Results: The high-expression rates of MUC1, MUC2 and Met were 66.1%, 61.0% and 61.0%, respectively, and the low-expression rates of them were 33.9%, 39.0% and 39.0%, respectively. The expression of Met was significantly correlated to the MUC1 and MUC2(P<0.01); while the expression of MUC1 was unrelated to MUC2(P>0.05). The lymph node metastasis in high-expression group of theses three markers was significantly higher than that in low-expression group(P<0.01), and no relationship was found between degree of differentiation and expression rate(P>0.05).The expression rate of MUC2 was significantly different among the four T groups(P<0.01).The survival rate was significantly higher in high-expression rate group of MUC1, MUC2 and Met(P<0.01). Conclusion: The expression of MUC1, MUC2 and Met may be involved in carcinogenesis and progression in hypopharyngeal carcinoma,and the detecting of MUC1,MUC2 and Met may be predicting its prognosis in hypopharyngeal carcinoma.