T细胞淋巴瘤中MUM1蛋白的表达及其与细胞增殖的关系

目的：探讨T细胞淋巴瘤中MUM1蛋白的表达及其与肿瘤细胞增殖的关系。方法：收集诊断及分型均明确的T细胞淋巴瘤患者的石蜡包埋组织58例,其中T淋巴母细胞性淋巴瘤/白血病（precursor Tlymphoblastic lymphoma/leukemia,T-LBL/L）9例、间变性大细胞淋巴瘤（anaplastic large Tcell lymphoma,ALCL）12例和外周T细胞性淋巴瘤（peripheral Tcell lymphoma,PTL）37例。另选2例反应性增生性淋巴结炎组织作对照。应用免疫组织化学法检测各组织中MUM1蛋白、ki-67的表达,并分析肿瘤组织中MUM1蛋白表达与ki-67增殖指数的关系。结果：1例T-LBL/L（1/9,11.11%）、9例ALCL（9/12,75.0%）和26例PTL（26/37,70.27%）组织中MUM1蛋白的表达呈阳性。MUM1蛋白在T-LBL/L中的阳性表达率明显低于ALCL组和PTL组（P〈0.05）,而在ALCL与PTL间的差别无统计学意义（P〉0.05）。MUM1蛋白阳性病例的ki-67增殖指数（53.61±23.83）%与MUM1阴性组（53.27±21.23）%相比,其差异无统计学意义（P〉0.05）。结论：MUM1蛋白在T细胞淋巴瘤中的表达可能与细胞活化有关,与肿瘤细胞的增殖可能无直接关系。

Expression of MUM1 protein in T-cell lymphoma and its relationship with cell proliferation

OBJECTIVE: To investigate the expression of MUM1 protein in T-cell lymphoma and its relationship with tumor cell proliferation.METHODS: The expressions of MUM1 protein and ki-67 in 58 specimens of T-NHL were analyzed by immunohistochemistry,including 9 cases of precursor T lymphoblastic lymphoma/leukemia(T-LBL/L),12 cases of anaplastic large T cell lymphoma(ALCL) and 37 cases of peripheral T cell lymphoma(PTL).Two cases of reactive hyperplastic lymphadenitis were used as comparison.We also analysed the rela...