还原型谷胱甘肽治疗糖尿病肾病的临床观察

目的 研究还原型谷胱甘肽(GSH)对糖尿病肾病的治疗作用.方法 将符合入选条件的糖尿病肾病(微量尿白蛋白期)患者随机分为3组,用不同剂量的GSH治疗,3周后观察尿微量白蛋白、肌酐、尿素氮、空腹血糖、早餐后2 h血糖、糖化血红蛋白的变化.结果 中等剂量GSH对糖尿病肾病患者无明显的治疗作用,而大剂量GSH能显著减少糖尿病肾病患者的尿微量白蛋白的含量,但对肌酐、尿素氮、糖化血红蛋白、空腹及早餐后2 h血糖无明显影响.结论 还原型谷胱甘肽对糖尿病肾病有一定的治疗作用.

Effects of reduced glutathione supplementation on patients with diabetic nephropathy

Objective To observe the effects of reduced glutathione on diabetic nephropathy. Methods Patients with diabetic nephropathy were divided into three groups in random. Microalbuminuria,blood urea nitrogen, serum creatinine,glycosylated hemoglobin,fasting plasma glucose and 2 h plasma glucose were measured. Results In microalbuminuria and glycosylated hemoglobin,there was statistically significant difference among groups after treatment with different dose of reduced glutathione. Statistically significant differences could be found in microalbuminuria between the groups treated with high dose of reduced glutathione and treated with zero dose. There were no statistically significant differences in blood urea nitrogen,serum creatinine,fasting plasma glucose and 2 h plasma glucose. Conclusion GSH is effective in patients with diabetic nephropathy.