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Serum uric acid as an index of impaired renal function in congestive heart failure
Authors:Tian Yu  Chen Ying  Deng Bao  Liu Gang  Ji Zhen-Guo  Zhao Qing-Zhen  Zhen Yu-Zhi  Gao Yan-Qiu  Tian Li  Wang Le  Ji Li-Shuang  Ma Guo-Ping  Liu Kun-Shen  Liu Chao
Affiliation:Emergency Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China;Emergency Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.;Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.
Abstract:

Background

Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid (UA) metabolism. This study was to assess their potential relations to UA metabolism in heart failure.

Methods

We retrospectively assessed clinical characteristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure (n = 553). By clustering of indices, those variables were explored using factor analysis.

Results

In factor analysis, serum uric acid (SUA) formed part of a principal cluster of renal functional variables which included serum creatinine (SCr) and blood urea nitrogen (BUN). Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN (r = 0.48, P < 0.001) and SCr (r = 0.47, P < 0.001).

Conclusions

There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.
Keywords:Serum uric acid   Heart failure   Renal function impairment   Factor analysis
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