NATRIURETIC AND HYPOTENSIVE EFFECTS OF α-HUMAN ATRIAL NATRIURETIC POLYPEPTIDE IN ANAESTHETIZED DOCA-SALT HYPERTENSIVE RATS |
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| Authors: | K Kondo O Kida K Kangawa H Matsuo K Tanaka |
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| Institution: | First Department of Internal Medicine, Miyazaki, Japan;*Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, Japan |
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| Abstract: | Both natriuretic and hypotensive effects of alpha-human atrial natriuretic polypeptide (alpha-hANP) were investigated in anaesthetized DOCA-salt hypertensive rats and control rats. An intravenous injection of two doses (0.3 and 3.0 micrograms/kg body weight) of alpha-hANP produced a rapid and marked increase in natriuresis and fall in blood pressure in DOCA-salt rats. Natriuretic and hypotensive effects of alpha-hANP in DOCA-salt rats were significantly greater than those in the control rats. It is suggested that DOCA-salt rats may have an enhanced natriuretic and hypotensive responsiveness to alpha-hANP. |
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| Keywords: | α-human atrial natriuretic polypeptide blood pressure DOCA-salt rats natriuresis |
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