Serum cytokines in patients with rheumatoid arthritis |
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Authors: | S. Sakito Y. Ueki K. Eguchi Y. Kawabe S. Nagataki |
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Affiliation: | (1) The First Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1-7-1, 852 Nagasaki city, Nagasaki, Japan;(2) Internal Medicine, Sasebo Central Hospital, Tonoo-cho 4-5, 857 Sasebo-city, Nagasaki, Japan |
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Abstract: | Serum cytokines such as interleukin 1 (IL-1), interferon (IFN-), and tumor necrosis factor (TNF) were measured in 40 patients with rheumatoid arthritis (RA). In the 40 patients studied, serum IL-1 was detected in 5 patients, IFN- in 10 patients, and TNF in 20 patients. The IL-1-positive group showed increased values of activity indices compared to the IL-1-negative group. Values of serum IFN- correlated well with the number of peripheral blood lymphocytes and CD3+ cells and with the percentage of CD3+ CD26+ cells. Values of serum TNF correlated positively with the number of peripheral blood monocytes and the percentage of CD3+ HLA-DR+ and CD3+ CD25+ cells. These results indicated that serum IL-1 in RA patients reflects the activity of RA, while the serum IFN- and TNF in RA patients may be related to circulating activated lymphocytes and monocytes, respectively. |
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Keywords: | Rheumatoid arthritis IL-1 /content/k20p034g4r400362/xxlarge946.gif" alt=" beta" align=" MIDDLE" BORDER=" 0" > TNF /content/k20p034g4r400362/xxlarge945.gif" alt=" agr" align=" BASELINE" BORDER=" 0" > IFN- /content/k20p034g4r400362/xxlarge947.gif" alt=" gamma" align=" MIDDLE" BORDER=" 0" > Activity index |
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