宫内感染与新生儿肺疾病

宫内感染和新生儿肺疾病如脓毒症/肺炎、呼吸窘迫综合征、支气管肺发育不良存在一定关系.宫内感染增加新生儿感染风险,可能发生脓毒症/肺炎;也增加了支气管肺发育不良发生率,但可能降低呼吸窘迫综合征发生率和严重性.近年来,各种动物实验研究有助于解释产前炎症对胎儿肺成熟、肺发育的影响.宫内感染可导致新生儿肺不良结局,但远期影响有待进一步观察.

Intrauterine infection and neonatal pulmonary outcomes

There is no consensus about the relationships between chorioamnionitis and 3 pulmonary outcomes of concern for preterm infants:respiratory distress syndrome,pneumonia/sepsis,and bronchopulmonary dysplasia.Intrauterine infection increases the risk of neonatal infection including sepsis/pneumonia,also increases the incidence of bronchopulmonary dysplasia,but may reduce the incidence and severity of respiratory distress syndrome.In recent years,translational research with various animal models has been helpful to answer basic questions about the effect of antenatal inflammation on maturation and development of the fetal lung and immune system.Although the mechanisms are not entirely clear,chorioamnionitis predisposes infants to premature birth,neonatal sepsis,and other adverse outcomes.In this article,we reviewed the relationship of intrauterine infection and neonatal pulmonary morbidity.