CPEB4在结直肠癌组织中表达及其与预后的关系

目的探讨CPEB4蛋白在结直肠癌组织中表达及其与患者临床病理参数和预后的相关性。方法应用免疫组织化学染色检测142例结直肠癌组织中CPEB4蛋白的表达状况。分析CPEB4蛋白表达与结直肠癌临床病理参数的关系及其对患者预后的影响。结果 CPEB4蛋白在结直肠癌组织中阳性表达率为56．34％（80／142），其表达与肿瘤直径（P＝0．037）、分化程度（P＝0．013）、肿瘤浸润深度（P＝0．013）、淋巴结转移（P＝0．011）、pTNM分期（P＝0．001）和Duke’s分期（P＜0．001）等临床病理参数有显著的相关性。CPEB4蛋白阳性表达患者预后较阴性表达者差（P＜0．001）。Cox多因素分析结果表明Duke’s分期（HR＝3．216，95％CI 2．21～4．68，P＜0．001）和CPEB4表达（HR＝6．264，95％CI 3．048～12．875，P＜0．001）是影响结直肠癌患者预后的独立影响因素。结论 CPEB4蛋白阳性表达可作为评价结直肠癌患者预后的评价指标之一。

CPEB4 expression and relationship with clinicopathology and prognosis in colorectal cancer

Objective To investigate the expression of CPEB4 protein and relationships with clinicopathological parameters and prognosis in colorectal cancer. Methods Clinicopathological data of 142 patients with colorectal cancer were retrospectively analyzed. The expression of CPEB4 protein was assessed by immunohistochemistry method in tumor tissues. The relationships of CPEB4 expression with clinicopathological parameters and prognosis were analyzed. Results The positive rate of CPEB4 expression in primary colorectal cancers was 56.34%(80/142).CPEB4 expression was significantly correlated with tumor size (P=0.037), Differentiation grade (P=0.013), Depth of invasion (P=0.013), Lymph node metastasis(P=0.011), pTNM staging(P=0.001) and Duke’s staging(P<0.001). CPEB4 positive expression indicated a worse prognosis in patients with colorectal cancer (P<0.001). Multivariant COX regression analysis revealed that Duke’s staging (HR=3.216, 95%CI 2.21-4.68, P<0.001) and CPEB4 expression (HR=6.264,95%CI 3.048-12.875,P<0.001) were independent prognostic factors for colorectal cancer patients. Conclusions The positive expression of CPEB4 was observed in colorectal cancer and CPEB4 in an independent prognostic factor for such population.