| 可溶性白细胞分化抗原14亚型在脓毒症中的研究进展 |
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| 引用本文： | 郑文娟,吴建新,任晓旭,祝益民. 可溶性白细胞分化抗原14亚型在脓毒症中的研究进展[J]. 中国小儿急救医学, 2016, 0(12): 846-851. DOI: 10.3760/cma.j.issn.1673-4912.2016.12.011 |
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| 作者姓名： | 郑文娟 吴建新 任晓旭 祝益民 |
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| 作者单位： | 1. 北京大学医学部首都儿科研究所教学医院重症医学科, 北京,100020;2. 北京大学医学部首都儿科研究所教学医院生物化学研究室, 北京,100020;3. 湖南省人民医院,长沙,410005 |
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| 基金项目： | 十二五国家科技支撑计划(2012BAI04B03)@@@@National Science and Technology Infrastructure Program during the 12th Five-Year Plan Period(2012BAI04B03) |
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| 摘 要： | 脓毒症是小儿危重症死亡的最重要和最常见的原因,病死率高,及时的诊断和治疗是提高生存率的关键因素之一。近年来,C-反应蛋白、降钙素原被用作诊断脓毒症的生物学标志物,但其敏感性和特异性有限,在非炎症情况下也会升高。可溶性白细胞分化抗原14亚型(又称presepsin)是一种存在于单核细胞/巨噬细胞中的糖蛋白。报道显示脓毒症患者体内的presepsin水平比健康者体内pr-esepsin水平显著升高,且与疾病严重程度相关。
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| 关 键 词： | 脓毒症 可溶性白细胞分化抗原14 降钙素原 |
Clinical research progress of presepsin on sepsis |
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| Abstract: | Sepsis is a frequent condition with high mortality,and its early diagnosis in the pediatrics department is one of the keys to improve survival. C-reactive protein and procalcitonin have been used as bio-markers in the diagnosis of sepsis,but they have limited susceptibility and specificity,and can be elevated in non inflammatory condition. Presepsin is the free fragment of a glycoprotein expressed on monocytes/macro-phages. Preliminiary reports suggest that levels of presepsin are significantly higher in septic patients com-pared to healthy individuals, and presepsin is useful for evaluating the severity of sepsis. |
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| Keywords: | Sepsis Presepsin Procalcitonin |
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