| 线粒体基因突变与原发性高血压及左心室肥厚的相关研究 |
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| 引用本文： | 朱海燕,王士雯,沈洪,刘丽,李彦华,陈瑞,王琳,李泱,朱庆磊. 线粒体基因突变与原发性高血压及左心室肥厚的相关研究[J]. 临床心血管病杂志, 2009, 25(9) |
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| 作者姓名： | 朱海燕 王士雯 沈洪 刘丽 李彦华 陈瑞 王琳 李泱 朱庆磊 |
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| 作者单位： | 解放军总医院急诊科,北京,100853;解放军总医院老年心血管病研究所;中国医学科学院北京协和医科大学,阜外心血管病医院 |
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| 基金项目： | 首都发展基金重点项目(No:2013-2019) |
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| 摘 要： | 目的:探讨线粒体基因突变在原发性高血压(EH)及左心室肥厚发病机制中作用,为临床诊断和治疗EH提供新的思路。方法:选择2006-01-2007-01之间540例EH患者,分为左心室肥厚组(270例)和非肥厚组(270例),进行线粒体突变位点及频率分析。270例健康体检者设为对照组。结果:肥厚组及非肥厚组患者突变位点和频率未发现显著性差异。与对照组比较,肥厚组及非肥厚组C8414T(P=0.01),A8701G(P=0.0001)均差异有统计学意义。结论:线粒体位点突变与EH左心室肥厚关系不甚密切,但是一些特殊位点的点突变因其对线粒体功能的影响,值得进一步研究。A8701G与C8414T突变可能影响了EH的发生发展进程。
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| 关 键 词： | 高血压 线粒体基因 左心室肥厚 |
Relationship between mitochondrial mutations, essential hypertension and left ventricular hypertrophy |
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| ZHU Haiyan WANG Shiwen SHEN Hong LIU Li LI YanhuaCHEN Rui WANG Lin LI Yang ZHU Qinglei. Relationship between mitochondrial mutations, essential hypertension and left ventricular hypertrophy[J]. Journal of Clinical Cardiology, 2009, 25(9) |
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| Authors: | ZHU Haiyan WANG Shiwen SHEN Hong LIU Li LI YanhuaCHEN Rui WANG Lin LI Yang ZHU Qinglei |
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| Affiliation: | 1Emergency Department;General Hospital of Chinese PLA;Beijing 100853;China;2Institute of Cardiovascular Disease;3Fuwai Hospital for Cardiovascular Disease;Chinese Academy of Medical Sciences and Peking Medical College |
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| Abstract: | Objective:To investigate the role of mitochondrial mutations in the pathogenesis of essential hypertension and left ventricular hypertrophy,and to find a new way to diagnose and treat hypertension. Method:We recruited 540 outpatients or in-patients at the General Hospital of PLA from January 2006 to January 2007. They were divided into hypertrophy and non-hypertrophy group,besides 270 healthy individuals as control. And sequence analyses were performed at the hotspots of mitochondrial DNA. Result:There were... |
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| Keywords: | hypertension mitochondrial genome left ventricular hypertrophy |
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