Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers |
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| Authors: | Jr" target="_blank">Missak HaigentzJr Carlos Suarez Primoz Strojan Juan P Rodrigo Alessandra Rinaldo Carol R Bradford June Corry Robert P Takes Alfio Ferlito |
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| Institution: | 1.Division of Oncology, Department of Medicine,Morristown Medical Center/Atlantic Health System,Morristown,USA;2.Departments of Medicine (Oncology) and Otorhinolaryngology-Head & Neck Surgery,Albert Einstein College of Medicine,Bronx,USA;3.Instituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo,Oviedo,Spain;4.Department of Radiation Oncology,Institute of Oncology,Ljubljana,Slovenia;5.Department of Otolaryngology,Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, CIBERONC,Oviedo,Spain;6.University of Udine School of Medicine,Udine,Italy;7.Department of Otolaryngology,University of Michigan,Ann Arbor,USA;8.GenesisCare Radiation Oncology, Division Radiation Oncology,St. Vincent’s Hospital,Melbourne,Australia;9.Department of Otolaryngology-Head and Neck Surgery,Radboud University Medical Center,Nijmegen,The Netherlands;10.Coordinator of the International Head and Neck Scientific Group,Padua,Italy |
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| Abstract: | The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation. |
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